David Wedge is a Professor of Cancer Genomics and Data Science at the Manchester Cancer Research Centre, University of Manchester. He was co-lead of the Evolution and Heterogeneity working group of the ICGC Pan-Cancer Analysis of Whole Genomes (PCAWG) project and is currently one of the leaders of the Pan Prostate Cancer Group (PPCG). Much of the research in the Wedge lab is focused on tumour evolution, from the initial transformation of normal cells to cancer, through the acquisition of treatment resistance and to the formation of metastatic lesions. We are also interested in how factors in the tumour microenvironment, such as hypoxia and immune cell populations, affect the course of tumour evolution. The Wedge group have pioneered the development of several computational methods to study heterogeneity in primary and metastatic cancers. In recent years, the focus of the lab has shifted towards Africa, including studies of breast cancer in Nigeria, prostate cancer in South Africa and oesophageal cancer in Kenya.